A neuroma is a thickening or enlargement of nerve tissue, which is often caused by irritation or compression of a nerve. This is the most common type of neuroma in the foot and usually occurs at the base of the third and fourth toes. A sharp or dull pain is usually felt between the third and fourth toes, which can be aggravated by wearing tight shoes and by walking. You may also feel numbness, tingling, or a burning sensation around the area. Treatment aims to reduce and relieve pressure around the nerve. It might include footwear modification or orthotics (insoles) to modify the forces acting on the joints and muscles of your feet and increase the space between your toes, thereby reducing pain.